Product Description

MDGA1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES10944-50, ES10944-100

Lead times: approximately 7-10 business days, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that is expressed predominantly in the developing nervous system. In addition to possessing several cell adhesion molecule-like domains, the mature protein has six Ig-like domains, a single fibronectin type III domain, a MAM domain and a C-terminal GPI-anchoring site. Studies in other mammals suggest this protein plays a role in cell adhesion, migration, and axon guidance and, in the developing brain, neuronal migration. In humans, this gene is associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2016],

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from part region of human protein

Isotype: IgG

Target: MDGA1,

Specificity: MDGA1 Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formulation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Has been found in brain, heart, skeletal muscle and kidney. Found to be overexpressed in tumor tissues.

Observed Band (KD): 105kD

Function: Required for radial migration of cortical neurons in the superficial layer of the neocortex. Similarity: Contains 1 fibronectin type-III domain. Similarity: Contains 1 MAM domain. Similarity: Contains 6 Ig-like (immunoglobulin-like) domains. Subcellular Location: Associated with lipid rafts. Subunit: Interacts heterophilically through its MAM domain with proteins in axon-rich regions and through its Ig-like domains with proteins in differentiating muscle. Tissue Specificity: Has been found in brain, heart, skeletal muscle and kidney. Found to be overexpressed in tumor tissues.

Subcellular Location: Cell membrane, Lipid-anchor, GPI-anchor Associated with lipid rafts.

Storage and Stability: -20°C/1 year

Gene Name: MDGA1, MAMDC3

Protein Name: MAM domain-containing glycosylphosphatidylinositol anchor protein 1, GPI and MAM protein, GPIM, Glycosylphosphatidylinositol-MAM, MAM domain-containing protein 3

Human Gene ID: 266727

Human SwissProt Number: Q8NFP4

Mouse SwissProt Number: Q0PMG2

Rat SwissProt Number: P85171

Research Use Only