Product Description

MDM2 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2033-50, BT-MCA2033-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

Research Areas: Cell Biology

Target Protein: MDM2

Applications: IHC, FCM

Clonality: Monoclonal

Clone ID: 3C1E3

Host: Mouse

Isotype: Mouse IgG2b

Full Product Name: MDM2

Immunogen: Purified recombinant fragment of human MDM2 (AA: 26-169) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 55.2kDa

UniProt Accession: Q00987

Synonyms: HDMX, LSKB, hdm2, ACTFS

GeneID: 4193

Research Use Only