Product Description

MEF2A (Acetyl-K403) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS64105-50, BS64105-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: MEF2A is a member of the MEF2 (myocyte enhancer factor 2) family of transcription factors. In mammals, four MEF2A-related genes (MEF2A, MEF2B, MEF2C and MEF2D) encode proteins which exhibit significant amino acid sequence similarity within their DNA binding domains and to a lesser extent throughout the remaining proteins. The MEF2 family members were originally described as muscle-specific DNA binding proteins that recognize MEF2 motifs found within the promoters of many muscle-specific genes. Phosphorylation of MEF2A at Thr312 and Thr319 within the transcription activation domain by p38 MAP kinase enhances MEF2A-MEF2D heterodimer-dependent gene expression. On the other hand, apoptotic stimμli (e.g. neurotoxic insμlt) resμlt in CDK5-dependent phosphorylation of MEF2A at Ser408 within the activation domain, inhibiting MEF2A pro-survival function.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Myocyte-specific enhancer factor 2A, Serum response factor-like protein 1, MEF2A, MEF2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Acetylated

Immunogen: Synthetic Acetylated peptide derived from human MEF2A around the acetylation site of lysine 403.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 96% (by SDS-PAGE).

Specificity: MEF2A (Acetyl- -K403) polyclonal antibody detects endogenous levels of MEF-2 protein only when acetylated at Lys403.

Molecular Weight: ~ 54 kDa

Pathway: Signaling Pathways Activating p38 MAP Kinase, Examples of Crosstalk Between Post-translational Modifications,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q02078

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only