MEK-2 Monoclonal Antibody - BT-MCA0875

MEK-2 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA0875-50, BT-MCA0875-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.

Research Areas: Signal transduction; Cancer

Target Protein: MAP2K2

Applications: WB, IF, ICC, FCM, ELISA

Reactivity: Human,Mouse,Rat

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Dual specificity mitogen-activated protein kinase kinase 2

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P36507; Mouse: Q63932; Rat: P36506

Synonyms: MAP2K2; MEK2; MKK2; PRKMK2; Dual specificity mitogen-activated protein kinase kinase 2; MAP kinase kinase 2; MAPKK 2; ERK activator kinase 2; MAPK; ERK kinase 2; MEK 2

GeneID: Human: 5605; Mouse: 26396; Rat: 58960

Research Use Only