Product Description

Melanopsin Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA27183-50, RA27183-100

Citations, Manuals and MSDS Available upon request.

Background: opsin 4 (OPN4) Homo sapiens Opsins are members of the guanine nucleotide-binding protein (G protein) -coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by Ref

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.

Alternative Names: OPN4; MOP; Melanopsin; Opsin-4

Applications: WB; IF/ICC; ELISA

Species Cross-Reactivity: Human; Rat; Mouse

GeneID (Human): 94233

Protein MW (KDa): 55

SWISS: Q9UHM6

Source: Rabbit

Research Use Only