Methyl-HP1 gamma/CBX3-H175 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A18812-20, A18812-100
Citations, Manuals and MSDS Available upon request.
Background: At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.
Category: Methylated Antibodies
Applications: DB, ELISA
Cross-reactivity: Human
Protein Weight: 21kDa
Observed Molecular Weight: Refer to figures
Immunogen: Recombinant protein (or fragment) .
Species: Human
GeneID: 11335
SWISS: Q13185
Alternate Names: HECH; HP1-GAMMA; HP1Hs-gamma; Methyl-HP1 gamma/CBX3-H175
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH 7.3.
Recommended Dilutions: DB, 1:500 - 1:1000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Epigenetics Nuclear Signaling, Protein phosphorylation.
NCBI Alias: CBX3
Research Use Only