Product Description

METTL4 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS71800-50, BS71800-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: N(6-adenine-specific methyltransferase that can methylate both RNAs and DNA. Acts as a N(6-adenine-specific RNA methyltransferase by catalyzing formation of N6, 2'-O-dimethyladenosine (m6A(m on internal positions of U2 small nuclear RNA (snRNA: methylates the 6th position of adenine residues with a pre-deposited 2'-O-methylation. Internal m6A(m methylation of snRNAs regμlates RNA splicing. Also able to act as a N(6-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6-methyladenosine. The existence of N(6-methyladenosine (m6A on DNA is however unclear in mammals, and additional evidences are required to confirm the role of the N(6-adenine-specific DNA methyltransferase activity of METTL4 in vivo. Acts as a regμlator of mitochondrial transcript levels and mitochondrial DNA (mtDNA copy number by mediating mtDNA N(6-methylation: m6A on mtDNA reduces transcription by repressing TFAM DNA-binding and bending. N(6-methyladenosine deposition by METTL4 regμlates Polycomb silencing by triggering ubiquitination and degradation of sensor proteins ASXL1 and MPND, leading to inactivation of the PR-DUB complex and subsequent preservation of Polycomb silencing (By similarity.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF/ICC

Alternate Names: METTL4, HsT661

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human METTL4(NP_073751.3).

Dilution: WB, 1:1000 - 1:2000 IHC, 1:50 - 1:200 IF/ICC, 1:50 - 1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Polyclonal Antibodies

Molecular Weight: 54kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q8N3J2

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only