Product Description

Mi2- Alpha Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA0885-50, BT-MCA0885-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.

Research Areas: Epigenetics and nuclear signaling; Immunology

Target Protein: CHD3

Applications: WB, IHC-p, IF, ICC, FCM

Reactivity: Human,Mouse,Rat,Bovine,Dog,Pig

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Chromodomain-helicase-DNA-binding protein 3

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q12873

Synonyms: CHD3; Chromodomain-helicase-DNA-binding protein 3; CHD-3; ATP-dependent helicase CHD3; Mi-2 autoantigen 240 kDa protein; Mi2-alpha; Zinc finger helicase; hZFH

GeneID: Human: 1107

Research Use Only