MLH1 Monoclonal Antibody - BT-MCA3764

MLH1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3764-50, BT-MCA3764-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC).

Research Areas: Epigenetics and Nuclear Signaling

Target Protein: MLH1

Applications: ICC, FCM

Clonality: Monoclonal

Clone ID: 8C12B7

Host: Mouse

Isotype: Mouse IgG2b

Full Product Name: MLH1

Immunogen: Purified recombinant fragment of human MLH1 (AA: 381-483) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 84.6kDa

UniProt Accession: P40692

Synonyms: FCC2, COCA2, HNPCC, hMLH1, HNPCC2

GeneID: 4292

Research Use Only