Product Description

MLK4 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES2799-50, ES2799-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation.,function:Activates the JUN N-terminal pathway.,PTM:Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH3 domain.,subunit:Homodimer.,

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA, IHC

Alternate Names: MLK4, KIAA1804, Mitogen-activated protein kinase kinase kinase MLK4, Mixed lineage kinase 4

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human MAP3KL4. AA range:631-680

Isotype: IgG

Target: MLK4

Specificity: MLK4 Polyclonal Antibody detects endogenous levels of MLK4 protein.

Dilution: WB 1:500-2000, IHC-p 1:50-300, ELISA 2000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Brain, Heart,

Observed Band (KD): 110kD

Function: Catalytic Activity: ATP + a protein = ADP + a phosphoprotein
Cofactor: Magnesium
Enzyme Regulation: Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation
Function: Activates the JUN N-terminal pathway
PTM: Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation
Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily
Similarity: Contains 1 protein kinase domain
Similarity: Contains 1 SH3 domain
Subunit: Homodimer

Subcellular Location: intracellular,

Storage and Stability: -20°C/1 year

Gene Name: MLK4

Protein Name: Mitogen-activated protein kinase kinase kinase MLK4

Mouse SwissProt Number: Q8VDG6

Research Use Only