MLKL Polyclonal Antibody - RA27282

MLKL Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA27282-50, RA27282-100

Citations, Manuals and MSDS Available upon request.

Background: mixed lineage kinase domain like (MLKL) Homo sapiens This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF) -induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Alternative Names: MLKL; Mixed lineage kinase domain-like protein

Applications: WB; ELISA

Species Cross-Reactivity: Human; Rat; Mouse

GeneID (Human): 197259

Protein MW (KDa): 55

SWISS: Q8NB16

Source: Rabbit

Research Use Only