MLL Monoclonal Antibody - BT-MCA3428

MLL Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3428-50, BT-MCA3428-100

Citations, Manuals and MSDS Available upon request.

Background: Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila). Eukaryotic RNA polymerase II mediates the synthesis of mature and functional messenger RNA. This is a multistep process, called the transcription cycle,that includes five stages: preinitiation, promoter, clearance, elongation and termination. Elongation is thought to be a critical stage for the regulation of gene expression. ELL (11-19 lysine-rich leukemia protein, also designated MEN) functions as an RNA polymerase II elongation factor that increases the rateof transcription by suppressing transient pausing by RNA polymerase II. Also, ELL is thought to regulate cellular proliferation. ELL is abundantly expressed in peripheral blood leukocytes, skeletal muscle, placenta and testis, and has lower expression in spleen, thymus, heart, brain, lung, kidney, liver and ovary.The gene encoding human ELL, which maps to chromosome 19p13.1, is one of several genes which undergo translocation with the MLL gene on chromo-some 11q23 in acute myeloid leukemia. MLL (myeloid/lymphoid leukemia,also designated ALL-1 and HRX) is a 430 kDa protein that regulates embryonal and hematopoietic development.

Research Areas: Epigenetics and nuclear signaling, Cancer

Target Protein: MLL

Applications: IHC

Reactivity: Human

Clonality: Monoclonal

Clone ID: 10F8D7

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: MLL

Immunogen: Purified recombinant fragment of MLL (aa3751-3968) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

UniProt Accession: Q03164

Synonyms: MLL

GeneID: 4297

Research Use Only