Product Description

MLXPL Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES14932-50, ES14932-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA, IHC

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human MLXPL AA range: 303-353

Isotype: IgG

Target: MLXPL

Specificity: This antibody detects endogenous levels of MLXPL at Human/Mouse/Rat

Dilution: WB 1:500-2000, IHC-p 1:50-300, ELISA 2000-20000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in liver, heart, kidney, cerebellum and intestinal tissues,

Molecular Weight (Da): 94kD

Fields: Insulin resistance, Non-alcoholic fatty liver disease

Function: Disease: Haploinsufficiency of WBSCR14 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS) [MIM: 194050]. WBS is a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23
Function: Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'
Similarity: Contains 1 basic helix-loop-helix (bHLH) domain
Subunit: Binds DNA as a heterodimer with TCFL4/MLX
Tissue Specificity: Expressed in liver, heart, kidney, cerebellum and intestinal tissues

Subcellular Location: Nucleus

Storage and Stability: -20°C/1 year

Gene Name: MLXIPL BHLHD14 MIO WBSCR14

Protein Name: MLXPL

Mouse Gene ID: 58805

Mouse SwissProt Number: Q99MZ3

Rat Gene ID: 171078

Rat SwissProt Number: Q8VIP2

Research Use Only