Product Description

MMP2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS72289-50, BS72289-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellμlar matrix and molecμles involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellμlarly by proteases, or, intracellμlary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in mμltiple pathways including roles in the nervous system, endometrial menstrual breakdown, regμlation of vascμlarization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodμlosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing resμlts in mμltiple transcript variants encoding different isoforms.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF/ICC

Alternate Names: CLG4, CLG4A, MMP-2, MMP-II, MONA, TBE-1, MMP2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human MMP2(NP_004521.1).

Dilution: WB, 1:500 - 1:2000 IHC, 1:50 - 1:200 IF/ICC, 1:50 - 1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Polyclonal Antibodies

Molecular Weight: 72KDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P08253

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only