Product Description

MNDA (V406) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS3332-50, BS3332-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P41218

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC

All Applications: IHC: 1:50~1:200

Background: Interferon-inducible proteins include IFI-202, IFI-203, IFI-204 and D3, which are encoded by six or more structurally related and IFN-inducible mouse genes mapping at the q21-q23 region of chromosome 1. The proteins encoded by these genes have homologous 200 amino acid segments. IFI-202 is a 52 kDa, primarily nuclear phosphoprotein which inhibits cell growth, in part by modulating transcriptional activity of NFκB, E2F, AP-1 and p53. Two related human proteins, MNDA (myeloid cell nuclear differentiation antigen) and IFI-16, have also been described. Expression of MNDA has been observed specifically in cells of the granulocyte-macrophage lineage. IFI-16 is constitutively expressed in various T and B cell lines and can be induced by IFN-γ in HL60 cells. At least four of the Gene 200 cluster of IFN-inducible proteins, IFI-202, IFI-204, MNDA and IFI-16, are localized in the nucleus.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: MNDA (V406) polyclonal antibody detects endogenous levels of MNDA protein.

Bioworld Molecular Weight: ~ 46 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of MNDA (V406) pAb in paraffin-embedded human tonsil carcinoma tissue at 1:5000. cytoplasmic and nucleus staining. Negative control (the right) Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase., Immunohistochemistry (IHC) analyzes of MNDA (V406) pAb in paraffin-embedded human kidney carcinoma tissue at 1:5000. cytoplasmic and nucleus staining. Negative control (the right) Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.

Alternative Name: Myeloid cell nuclear differentiation antigen; MNDA

Immunogen: Synthetic peptide, corresponding to amino acids 380-430 of Human MNDA.

Conjugate: Unconjugated

Modification: Unmodified