Product Description

MPDZ Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES14723-50, ES14723-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene has multiple PDZ domains, which are hallmarks of protein-protein interactions. The encoded protein is known to interact with the HTR2C receptor and may cause it to clump at the cell surface. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA, IHC

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human MPDZ AA range: 1564-1614

Isotype: IgG

Target: MPDZ

Specificity: This antibody detects endogenous levels of MPDZ at Human/Mouse/Rat

Dilution: WB 1:500-2000, IHC-p 1:50-300, ELISA 2000-20000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas,

Molecular Weight (Da): 228kD

Fields: Tight junction

Function: Similarity: Contains 13 PDZ (DHR) domains

Subcellular Location: Cell membrane, Peripheral membrane protein, Cytoplasmic side Apical cell membrane, Peripheral membrane protein, Cytoplasmic side Cell junction, synapse, postsynaptic density Cell projection, dendrite Cell junction, tight junction Cell junction, synapse Cell junction, synapse, synaptosome Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells (By similarity) Highly enriched in postsynaptic densities (PSD) Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4 Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells (By similarity) In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane Enriched at the tight junctions

Storage and Stability: -20°C/1 year

Gene Name: MPDZ MUPP1

Protein Name: MPDZ

Mouse Gene ID: 17475

Mouse SwissProt Number: Q8VBX6

Rat Gene ID: 29365

Rat SwissProt Number: O55164

Research Use Only