MPL Monoclonal Antibody - BT-MCA2635

MPL Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2635-50, BT-MCA2635-100

Citations, Manuals and MSDS Available upon request.

Background: In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.

Research Areas: Immunology

Target Protein: MPL

Applications: FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 1H2

Host: Mouse

Isotype: Mouse IgG2b

Full Product Name: MPL

Immunogen: Purified recombinant fragment of human MPL expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 71.2kDa

UniProt Accession: P40238

Synonyms: MPLV, TPOR, C-MPL, CD110

GeneID: 4352

Research Use Only