MRE11 Monoclonal Antibody - BT-MCA4568

MRE11 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4568-50, BT-MCA4568-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Research Areas: Others

Target Protein: MRE11

Applications: WB, IHC, FCM

Reactivity: Human, Mouse, Monkey, Rat

Clonality: Monoclonal

Clone ID: 7C8A9

Host: Mouse

Isotype: Mouse IgG2b

Full Product Name: MRE11

Immunogen: Purified recombinant fragment of human MRE11 (AA: 182-582) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 80.6kDa

UniProt Accession: P49959

Synonyms: ATLD, HNGS1, MRE11A, MRE11B

GeneID: 4361

Research Use Only