MSH6 Monoclonal Antibody - BT-MCA2506

MSH6 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2506-50, BT-MCA2506-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.

Research Areas: Epigenetics and Nuclear Signaling

Target Protein: MSH6

Clonality: Monoclonal

Clone ID: 1D10G1

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: MSH6

Immunogen: Purified recombinant fragment of human MSH6 (AA: 217-395) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 152.8kDa

UniProt Accession: P52701

Synonyms: GTBP, HSAP, p160, GTMBP, HNPCC5

GeneID: 2956

Research Use Only