Product Description

MSY2 (G311) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS2169-50, BS2169-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9Y2T7

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC, IF

All Applications: IHC: 1:50~1:200
IF: 1:50~1:200

Background: Contrin (MSY2 in mouse) and YB-2 (MSY3/4 in mouse) belong to the Y-box family of multifunctional proteins that regulate both transcription and translation.Y-box proteins interact with a wide variety of nucleic acid structures to act as transcription factors and mRNA masking proteins. The modular structure of Y-box proteins includes a highly conserved N-terminal cold-shock domain (CSD, equivalent to the bacterial cold-shock proteins) and four basic C-terminal domains containing arginine clusters and aromatic residues. MSY2 (Contrin) is a expressed in testis and ovary, where it may repress translation of parental mRNA. The gene encoding human Contrin maps to chromosome 17p11.2-13.1. MSY3/4 (YB-2) is also known as DNA binding protein A and is highly expressed in testis, heart and muscle. Contrin and YB-2 bind to the consensus sequence 5'-UCCAUCA-3' contained in the Y-box element .

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of MSY2 (G311) pAb in paraffin-embedded human kidney carcinoma tissue at 1:50. showing cytoplasmic and nucleus staining. Negative control (the right) Using PBS instead of primary antibody,Secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.

Bioworld Molecular Weight: ~ 38 kDa

Specificity: MSY2 (G311) polyclonal antibody detects endogenous levels of MSY2 protein.

Alternative Name: Y-box-binding protein 2; Contrin; DNA-binding protein C; Dbpc; Germ cell-specific Y-box-binding protein; MSY2 homolog; YBX2; CSDA3; MSY2

Immunogen: Synthetic peptide, corresponding to amino acids 287-325 of Human MSY2.

Conjugate: Unconjugated

Modification: Unmodified