MUC6 Monoclonal Antibody Sizes: 50μl, 100μl Catalogue Numbers: MB66084-50, MB66084-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: Mucin 6 (also designated MUC 6 and gastric mucin) is a large glycoprotein that plays a major role in the protection of the gastrointestinal tract. Mucin 6 carries GlcNAca1Æ4GalβÆR structures, indicating that a1, 4-N-acetylglucosaminyltransferase is important to the formation of the mucous glycoproteins in vivo. Mucin 6 expression is highest in the stomach and gall bladder, with lower expression in the terminal ileum and right colon. In gastric cancer, Mucin 6 has an altered expression. In normal stomach, Mucin 6 apomucin is associated with Lewis type 2, Mucin 6 is also expressed in gastric metaplasia, duodenum and pancreas. Mucin 6 is a secretory mucin, located in the deeper mucosal folds of human gall bladder, and its expression is altered with increasing degrees of inflammation. Mucin 6 mRNA is expressed transiently in the nephrogenic zone of the kidney in the early mid-trimester of development, and Mucin 6 glycoprotein is expressed in the epithelium of ureteric buds and collecting ducts, but absent from adμlt kidney. Proliferating bile ductμlar cells express Mucin 6 apomucin in diseased liver, especially in chronic viral hepatitis with active necroinflammation, suggesting that this secreted mucin acts as a cytoprotective agent and represents a phenotype of reactive biliary epithelium in chronic viral hepatitis. Category: Primary Antibody Reactivity: Human Host: Mouse Applications: IHC Alternate Names: Mucin-6, MUC-6, Gastric mucin-6 Clonality: Monoclonal Conjugate: Unconjugated Modification: Unmodification Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within human MUC6. The exact sequence is proprietary. Dilution: IHC (1/100 - 1/300) Purification: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). Specificity: Recognizes endogenous levels of MUC6 protein. Molecular Weight: ~ 257 kDa Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. SwissProt: Q6W4X9 Product: Mouse IgG1. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide. Research Use Only