MUSK Monoclonal Antibody - BT-MCA4420

MUSK Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4420-50, BT-MCA4420-100

Citations, Manuals and MSDS Available upon request.

Background: MuSK (for Muscle Specific Kinase) is a receptor tyrosine kinase required for the formation of the neuromuscular junction (NMJ). It induces cellular signaling by causing the addition of phosphate molecules to particular tyrosines on itself, and on proteins which bind the cytoplasmic domain of the receptor. It is activated by a nerve-derived proteoglycan called agrin. During development, the growing end of motor neuron axons secrete a protein called agrin.This protein binds to several receptors on the surface of skeletal muscle. The receptor which seems to be required for formation of the neuromuscular junction (NMJ), which comprises the nerve-muscle synapse is called MuSK. MUSK mutations lead to decreased agrin-dependent AchR aggregation, a critical step in the formation of the neuromuscular junction.

Research Areas: Signal transduction, Tags and, cell markers

Target Protein: MUSK

Applications: IHC, ICC

Reactivity: Human

Clonality: Monoclonal

Clone ID: 10A4

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: MUSK

Immunogen: Purified recombinant extracellular fragment of human MUSK (aa24-209) fused with hIgGFc tag expressed in HEK293 cell line.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 97kDa

UniProt Accession: O15146

Synonyms: muscle, skeletal, receptor tyrosine kinase

GeneID: 4593

Research Use Only