MYL3 Monoclonal Antibody
Sizes: 50μL, 100μL
Catalogue Number: BT-MCA4544-50, BT-MCA4544-100
Citations, Manuals and MSDS Available upon request.
Background: Myosins are a large superfamily of motor proteins that move along actin filaments, while hydrolyzing ATP. Myosin is the major component of thick muscle filaments, and is a long asymmetric molecule containing a globular head and a long tail. The molecule consists of two heavy chains and four light chains. Activation of smooth and cardiac muscle primarily involves pathways which increase calcium and myosin phosphorylation resulting in contraction. Myosin light chain phosphatase acts to regulate muscle contraction by dephosphorylating activated myosin light chain. MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Human myosin light chain has clinical application as a cardiac marker. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy.
Research Areas: Signal Transduction
Target Protein: MYL3
Applications: WB, IHC
Reactivity: Human
Clonality: Monoclonal
Clone ID: 7C1
Host: Mouse
Isotype: Mouse IgG1
Full Product Name: MYL3
Immunogen: Purified recombinant fragment of MYL3 expressed in E. Coli.
Storage: 4°C|-20°C for long term storage
Formulation: Ascitic fluid containing 0.03% sodium azide.
Molecular Weight (Da): 22kDa
UniProt Accession: P08590
Synonyms: CMH8, VLC1, MLC1V, MLC1SB
GeneID: 4634
Research Use Only