Product Description

MYSM1 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA27551-50, RA27551-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: catalytic activity:Ubiquitin C-terminal thioester + H (2)O = ubiquitin + a thiol., domain:Binds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA., function:Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the peptidase M67A family. MYSM1 subfamily., similarity:Contains 1 MPN (JAB/Mov34) domain., similarity:Contains 1 SANT domain., similarity:Contains 1 SWIRM domain., subunit:Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Binds histones.,

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, IHC-p, IF (paraffin section), ELISA

Alternate Names: MYSM1, KIAA1915, Histone H2A deubiquitinase MYSM1, 2A-DUB, Myb-like, SWIRM and MPN domain-containing protein 1

Clonality: Polyclonal

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

Molecular Weight: 95

Protein Molecular Weight (kDa): 95

Storage: -20°C/1 year

Human Gene ID: 114803

Human SwissProt Number: Q5VVJ2

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only