N-CoR Monoclonal Antibody - BT-MCA0932

N-CoR Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA0932-50, BT-MCA0932-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.

Research Areas: Epigenetics and Nuclear Signaling; Signal Transduction; Cancer; Metabolism

Target Protein: NCOR1

Applications: WB, IHC-p, IF, ELISA

Reactivity: Human

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Nuclear receptor corepressor 1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: O75376; Mouse: Q60974

Synonyms: NCOR1; KIAA1047; Nuclear receptor corepressor 1; N-CoR; N-CoR1

GeneID: Human: 9611

Research Use Only