Product Description

Na+ CP-Pan (K1493) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS1328-50, BS1328-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P35498/Q99250/Q9NY46/P35499/Q14524/Q9UQD0/Q15858/Q9Y5Y9/Q9UI33

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC, IF

All Applications: IHC: 1:50~1:200
IF: 1:50~1:200

Background: Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddel’s syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of Na+ CP-pan (K1493) pAb in paraffin-embedded human colorectal carcinoma tissue at 1:50.

Bioworld Molecular Weight: ~ 230 kDa

Specificity: Sodium Channel-pan (K1493) polyclonal antibody detects endogenous levels of Sodium Channel-pan protein.

Alternative Name: SCN2A; NAC2, SCN2A1, SCN2A2; Nav1.1; NAC1; SCN1; SCN1A; Nav1.2; SCN3A; KIAA1356, NAC3; Nav1.3; Nav1.4; SCN4A; Nav1.5; SCN5A; Nav1.6; SCN8A; MED; Nav1.7; SCN9A; NENA; Nav1.8; SCN10A; Nav1.9; hNaN; SCN11A; SCN12A; SNS2

Immunogen: Synthetic peptide, corresponding to amino acids 1470-1520 of Human SCN5A.

Conjugate: Unconjugated

Modification: Unmodified