Product Description

Na+ CP-pan (K1493) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS1328-50, BS1328-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellμlar amino and carboxyl termini, two short membrane spanning segments, and a large extracellμlar loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regμlating blood pressure. ENaC is thought to be regμlated, in part, through association with the cystic fibrosis transmembrane conductance regμlator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddel’s syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC, IF

Alternate Names: SCN2A, NAC2, SCN2A1, SCN2A2, Nav1.1, NAC1, SCN1, SCN1A, Nav1.2, SCN3A, KIAA1356, NAC3, Nav1.3, Nav1.4, SCN4A, Nav1.5, SCN5A, Nav1.6, SCN8A, MED, Nav1.7, SCN9A, NENA, Nav1.8, SCN10A, Nav1.9, hNaN, SCN11A, SCN12A, SNS2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 1470-1520 of Human SCN5A.

Dilution: IHC: 1:50~1:200
IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Sodium Channel-pan (K1493) polyclonal antibody detects endogenous levels of Sodium Channel-pan protein.

Molecular Weight: ~ 230 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P35498/Q99250/Q9NY46/P35499/Q14524/Q9UQD0/Q15858/Q9Y5Y9/Q9UI33

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only