Product Description

NCX1 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA27630-50, RA27630-100

Citations, Manuals and MSDS Available upon request.

Background: solute carrier family 8 member A1 (SLC8A1) Homo sapiens In cardiac myocytes, Ca (2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca (2+) concentration during contraction is primarily due to release of Ca (2+) from intracellular stores. However, some Ca (2+) also enters the cell through the sarcolemma (plasma membrane) . During relaxation, Ca (2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca (2+) that entered across the sarcolemma must be extruded from the cell. The Na (+) -Ca (2+) exchanger is the primary mechanism by which the Ca (2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

Alternative Names: SLC8A1; CNC; NCX1; Sodium/calcium exchanger 1; Na (+) /Ca (2+) -exchange protein 1

Applications: WB; ELISA

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 6546

Protein MW (KDa): 108

SWISS: P32418

Source: Rabbit

Research Use Only