Nebulette Polyclonal Antibody-BS65465

Nebulette Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS65465-50, BS65465-100

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Swiss-Prot: O76041

Host: Rabbit

Reactivity: Human, Mouse, Rat,

Applications: WB

All Applications: WB=1:500-2000

Background: Nebulette binds to actin and plays an important role in Z-disk assembly. It is a cardiac homolog of nebulin and its expression is abundant in cardiac muscle. Nebulette defects are assocated with non-familial idiopathic cardiacmyopathy.
Nebulin and nebulette are homologous thin-filament associated proteins expressed in skeletal and cardiac muscles, respectively. Nebulette, unlike nebulin, is confined to the Z-disc region of the sarcomere and does not span the whole thin filament length. Nebulette colocalizes with α-actinin in the pre-, nascent, and mature myofibrils. A polymorphism in the actin-binding motif of nebulette is a genetic marker of susceptibility to nonfamilial idiopathic dilated cardiomyopathy (IDC), characterized by a thin-walled heart and systolic dysfunction.

Purification and Purity: affinity purified by Protein A

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Nebulette Polyclonal Antibody detects endogenous levels of Nebulette protein.

Bioworld Molecular Weight: 116 kD

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Primary: Anti- Nebulette at 1/1000 dilution

Alternative Name: Actin binding Z disk protein; bA56H7.1; LIM nebulette; LNEBL; NEBL; NEBL_HUMAN.

Immunogen: KLH conjugated synthetic peptide derived from human Nebulette:321-420/1014

Conjugate: Unconjugated

Modification: Unmodified