Product Description

NEC1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES14532-50, ES14532-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene [provided by RefSeq, Jan 2014],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human NEC1 AA range: 125-175

Isotype: IgG

Target: NEC1

Specificity: This antibody detects endogenous levels of NEC1 at Human/Mouse/Rat

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Molecular Weight (Da): 83kD

Function: Catalytic Activity: Release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds
Cofactor: Calcium
Disease: Defects in PCSK1 are the cause of proprotein convertase 1 deficiency (PC1 deficiency) [MIM: 600955]. PC1 deficiency is characterized by obesity, hypogonadism, hypoadrenalism, reactive hypoglycemia as well as marked small-intestinal absorptive dysfunction It is due to impaired processing of prohormones
Function: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin
polymorphism: Genetic variations in PCSK1 define the body mass index quantitative trait locus 12 (BMIQ12) [MIM: 612362]. Variance in body mass index is a susceptibility factor for obesity
Similarity: Belongs to the pe

Subcellular Location: Cytoplasmic vesicle, secretory vesicle Localized in the secretion granules

Storage and Stability: -20°C/1 year

Gene Name: PCSK1 NEC1

Protein Name: NEC1

Mouse Gene ID: 18548

Mouse SwissProt Number: P63239

Rat Gene ID: 100911216

Rat SwissProt Number: P28840

Research Use Only