Product Description

NEDD4L (phospho-S448) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS74025-50, BS74025-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of mμltiple target substrates and plays a critical role in epithelial sodium transport by regμlating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding mμltiple isoforms have been observed for this gene.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: hNEDD4-2, NEDD4-2, NEDD4.2, PVNH7, RSP5, hNEDD4-2, NEDD4-2, NEDD4.2, RSP5

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: A synthetic phosphorylated peptide around S448 of human NEDD4L

Dilution: WB 1:500 - 1:2000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: NEDD4L (phospho-S448) polyclonal antibody detects endogenous levels of NEDD4L protein when phosphorylated at Ser448.

Molecular Weight: 130kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q96PU5

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only