NEDD4L (phospho-S448) Polyclonal Antibody-BS74025

NEDD4L (phospho-S448) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS74025-50, BS74025-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q96PU5

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB 1:500 - 1:2000

Background: This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of extracts of various cell lines, using Phospho-NEDD4L-S448 antibody.

Bioworld Molecular Weight: 130kDa

Specificity: NEDD4L (phospho-S448) polyclonal antibody detects endogenous levels of NEDD4L protein when phosphorylated at Ser448.

Alternative Name: hNEDD4-2; NEDD4-2; NEDD4.2; PVNH7; RSP5; hNEDD4-2; NEDD4-2; NEDD4.2; RSP5

Immunogen: A synthetic phosphorylated peptide around S448 of human NEDD4L

Conjugate: Unconjugated

Modification: Phosphorylation