NEDD8 Monoclonal Antibody - BT-MCA3074

NEDD8 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3074-50, BT-MCA3074-100

Citations, Manuals and MSDS Available upon request.

Background: Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.Tissue specificity: Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes.

Research Areas: Cell Biology

Target Protein: NEDD8

Applications: IHC, ICC, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 1A7

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: NEDD8

Immunogen: Purified recombinant fragment of human NEDD8 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 9kDa

UniProt Accession: Q15843

Synonyms: NEDD-8

GeneID: 4738

Research Use Only