NFKB1 Monoclonal Antibody - BT-MCA2641

NFKB1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2641-50, BT-MCA2641-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.

Research Areas: Cell Biology

Target Protein: NFKB1

Applications: WB, IHC, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 5D10

Host: Mouse

Isotype: Mouse IgG2a

Full Product Name: NFKB1

Immunogen: Purified recombinant fragment of human NFKB1 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 50kDa|105kDa

UniProt Accession: P19838

Synonyms: p50, KBF1, p105, EBP-1, MGC54151, NFKB-p50, NFkappaB, NF-kappaB, NFKB-p105, NF-kappa-B

GeneID: 4790

Research Use Only