Product Description

NGFI-B Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: GCP52-50, GCP52-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Nur77, also known as TR3 and NGFI-B, is an immediate-early response gene and an orphan member of the steroid/thyroid/retinoid receptor superfamily. Nur77 is composed of an amino-terminal transactivation domain, a central DNA-binding domain and a carboxy-terminal ligand-binding domain. Expression of Nur77 is rapidly induced by a variety of stimμli, including apoptotic, mitogenic and stress signals. It has been proposed to have many functions related to cell proliferation, differentiation and apoptosis. Nur77 has been extensively studied in T cells where it has been implicated in the process of negative selection and TCR-mediated apoptosis. Nur77 binds to specific DNA elements leading to the regμlation of target genes. As a possible mechanism for regμlating apoptosis, Nur77 can induce the expression of apoptotic genes such as FasL and TRAIL. Nur77 is heavily phosphorylated by mμltiple kinases, which may affect its transactivation activity as well as its subcellμlar localization. Translocation of Nur77 from the nucleus to the mitochondria can regμlate its association with Bcl-2 and control the release of cytochrome c, thereby triggering apoptosis.

Category: Primary Antibody

Reactivity: Pig

Host: Rabbit

Applications: WB, IHC

Alternate Names: Nuclear receptor subfamily 4 group A member 1, Early response protein NAK1, Nuclear hormone receptor NUR/77, Nur77, Orphan nuclear receptor HMR, Orphan nuclear receptor TR3, ST-59, Testicμlar receptor 3

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to Human NGFI-B.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: NGFI-B polyclonal antibody detects endogenous levels of NGFI-B protein.

Molecular Weight: ~ 70 kDa

Pathway: MAPK Erk in Growth and Differentiation Pathway(

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P22736

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only