Product Description

NMNA3 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES14476-50, ES14476-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the nicotinamide/nicotinic acid mononucleotide adenylyltransferase family. These enzymes use ATP to catalyze the synthesis of nicotinamide adenine dinucleotide or nicotinic acid adenine dinucleotide from nicotinamide mononucleotide or nicotinic acid mononucleotide, respectively. The encoded protein is localized to mitochondria and may also play a neuroprotective role as a molecular chaperone. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human NMNA3 AA range: 97-147

Isotype: IgG

Target: NMNA3

Specificity: This antibody detects endogenous levels of NMNA3 at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in lung and spleen with lower levels in placenta and kidney,

Molecular Weight (Da): 28kD

Fields: Nicotinate and nicotinamide metabolism, Metabolic pathways, Biosynthesis of cofactors

Function: Catalytic Activity: ATP + nicotinamide ribonucleotide = diphosphate + NAD(+)
Catalytic Activity: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD(+)
Cofactor: Divalent metal cations. Magnesium confers the highest activity
Enzyme Regulation: Activity is strongly inhibited by galotannin. Inhibited by P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate (Nap4AD)
Function: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form, nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD (+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotina

Subcellular Location: Mitochondrion

Storage and Stability: -20°C/1 year

Gene Name: NMNAT3 FKSG76

Protein Name: NMNA3

Mouse Gene ID: 74080

Mouse SwissProt Number: Q99JR6

Research Use Only