NNT-1 Polyclonal Antibody - RA27891

NNT-1 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA27891-50, RA27891-100

Citations, Manuals and MSDS Available upon request.

Background: cardiotrophin-like cytokine factor 1 (CLCF1) Homo sapiens This gene is a member of the glycoprotein (gp) 130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1) . CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1) . This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2) . This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encodin

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: IHC-p 1:50-200, ELISA 1:10000-20000

Alternative Names: Cardiotrophin-like cytokine factor 1 (B-cell-stimulating factor 3;BSF-3;Novel neurotrophin-1;NNT-1)

Applications: IHC-p; IF (paraffin section) ; ELISA

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 23529

SWISS: Q9UBD9

Source: Rabbit

Research Use Only