Product Description

NNT-1 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA27891-50, RA27891-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: cardiotrophin-like cytokine factor 1 (CLCF1) Homo sapiens This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encodin

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC-p, IF (paraffin section), ELISA

Alternate Names: Cardiotrophin-like cytokine factor 1 (B-cell-stimulating factor 3;BSF-3;Novel neurotrophin-1;NNT-1)

Clonality: Polyclonal

Dilution: IHC-p 1:50-200, ELISA 1:10000-20000

Storage: -20°C/1 year

Human Gene ID: 23529

Human SwissProt Number: Q9UBD9

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only