Product Description

Notch 2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS7044-50, BS7044-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Notch proteins (Notch1-4) are a family of transmembrane receptors that play important roles in development and the determination of cell fate. Mature Notch receptors are processed and assembled as heterodimeric proteins, with each dimer comprised of a large extracellμlar ligand-binding domain, a single-pass transmembrane domain, and a smaller cytoplasmic subunit (Notch intracellμlar domain, NICD). Binding of Notch receptors to ligands of the Delta-Serrate-Lag2 (DSL) family triggers heterodimer dissociation, exposing the receptors to proteolytic cleavages, these resμlt in release of the NICD, which translocates to the nucleus and activates transcription of downstream target genes. Notch2 is a member of the Notch family and mutation in Notch2 is associated with Alagille syndrome.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB, IHC

Alternate Names: Notch 2, Hn2, N2ECD, N2ICD, NOTCH2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Notch 2.

Dilution: WB: 1:500~1:1000
IP:1:100~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Notch 2 polyclonal antibody detects endogenous levels of Notch 2 protein.

Molecular Weight: ~ 110 kDa

Pathway: Notch Signaling, Contribution of Soluble Factors to EMT,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q04721

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Research Use Only