Product Description

NOTCH3 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB67250-50, MB67250-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Notch proteins (Notch1-4) are a family of transmembrane receptors that play important roles in development and the determination of cell fate. Mature Notch receptors are processed and assembled as heterodimeric proteins, with each dimer comprised of a large extracellμlar ligand-binding domain, a single-pass transmembrane domain, and a smaller cytoplasmic subunit (Notch intracellμlar domain, NICD). Binding of Notch receptors to ligands of the Delta-Serrate-Lag2 (DSL) family triggers heterodimer dissociation, exposing the receptors to proteolytic cleavages, these resμlt in release of the NICD, which translocates to the nucleus and activates transcription of downstream target genes. Notch3 is a member of the Notch family and is processed similar to Notch1 It is expressed primarily in arterial smooth muscle cells (SMC). Mutations altering the number of cysteine residues in the Notch3 extracellμlar region are associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a hereditary angiopathy leading to strokes and dementia in adμlts. Recent studies indicate that Notch3 is overexpressed in many types of cancer.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: Neurogenic locus notch homolog protein 3, Notch 3

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human NOTCH3. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of NOTCH3 protein.

Molecular Weight: ~ 230 kDa

Pathway: ESC Pluripotency and Differentiation Signaling Pathway, Notch Signaling

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9UM47

Product: Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only