NOTCH4 Monoclonal Antibody - BT-MCA3673

NOTCH4 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3673-50, BT-MCA3673-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Research Areas: Epigenetics and Nuclear Signaling

Target Protein: NOTCH4

Applications: IHC, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 6D8D4

Host: Mouse

Isotype: Mouse IgG2a

Full Product Name: NOTCH4

Immunogen: Purified recombinant fragment of human NOTCH4 (AA: extra 118-357) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 209.6kDa

UniProt Accession: Q99466

Synonyms: INT3

GeneID: 4855

Research Use Only