NPC1 Monoclonal Antibody - BT-MCA4824

NPC1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4824-50, BT-MCA4824-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.

Research Areas: Cardiovascular, Metabolism, Neuroscience, Signal transduction

Target Protein: NPC1

Applications: IHC, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 8D10G3

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: NPC1

Immunogen: Purified recombinant fragment of human NPC1 (AA: 34-174) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 142.2kDa

UniProt Accession: O15118

Synonyms: NPC

GeneID: 4864

Research Use Only