Product Description

NPW Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES9924-50, ES9924-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The product of this gene is processed into 23- and 30-amino acid neuropeptides that bind and activate two G-protein coupled receptors in the central nervous system. The neuropeptides have been shown to enhance cortisol secretion from adrenal cells through the adenylate cyclase/protein kinase A signaling cascade. The preproprotein is translated using a non-AUG initiation codon that is inferred from analyses of the mouse ortholog. [provided by RefSeq, Jul 2008],

Reactivity: Human, Rat

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human protein. at AA range: 90-170

Isotype: IgG

Target: NPW

Specificity: NPW Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Detected at high levels in the substantia nigra, fetal kidney and trachea, at lower levels in testis, uterus, ovary and placenta, Not detectable in many regions of the central nervous system, Also detected at high levels in lymphoblastic leukemia and colorectal adenocarcinoma,

Observed Band (KD): 18kD

Fields: Neuroactive ligand-receptor interaction

Function: Function: Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30
Similarity: Belongs to the neuropeptide B/W family
Tissue Specificity: Detected at high levels in the substantia nigra, fetal kidney and trachea, at lower levels in testis, uterus, ovary and placenta. Not detectable in many regions of the central nervous system. Also detected at high levels in lymphoblastic leukemia and colorectal adenocarcinoma

Subcellular Location: Secreted

Storage and Stability: -20°C/1 year

Gene Name: NPW PPL8 PPNPW

Protein Name: Neuropeptide W (Preproprotein L8) (hPPL8) [Cleaved into: Neuropeptide W-23 (NPW23) (hL8), Neuropeptide W-30 (NPW30) (hL8C)]

Rat SwissProt Number: Q8K1M5

Research Use Only