Product Description

NRAS Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66760-50, MB66760-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The mammalian Ras (also designated v-Ha-Ras, Harvey rat sarcoma viral oncogene homolog, HRAS1, K-Ras, N-Ras, RASH1 or c-bas/has) gene family consists of the Harvey and Kirsten Ras genes (c-H-Ras1 and c-K-Ras2), an inactive pseudogene of each (c-H-Ras2 and c-K-Ras1) and the N-Ras gene.The three Ras oncogenes, H-Ras, K-Ras and N-Ras, encode proteins with GTP/GDP binding and GTPase activity. Ras proteins alternate between an inactive form bound to GDP and an active form bound to GTP, activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). Ras nomenclature originates from the characterization of human DNA sequences homologous to cloned DNA fragments containing oncogenic sequences of a type C mammalian retrovirus, the Harvey strain of murine sarcoma virus (HaMSV), derived from the rat. Under normal conditions, Ras family members influence cell growth and differentiation events in a subcellμlar membrane compartmentalization-based signaling system. Oncogenic Ras can deregμlate processes that control both cell proliferation and apoptosis. The Ras superfamily of GTP hydrolysis-coupled signal transduction relay proteins can be subclassified into Ras, Rho, Rab and ARF families.

Category: Primary Antibody

Reactivity: Human, Rat

Host: Mouse

Applications: WB

Alternate Names: HRAS1, GTPase NRas, Transforming protein N-Ras

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human NRAS. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of NRAS protein.

Molecular Weight: ~ 19 kDa

Pathway: Regμlation of Actin Dynamics, Tumor Angiogenesis, ESC Pluripotency and Differentiation Signaling Pathway, ErbB HER Signaling, G Protein-coupled Receptors Signaling to MAPK Erk, MAPK Erk in Growth and Differentiation Pathway, Jak Stat: IL-6 Receptor Signaling, Inhibition of Apoptosis, SAPK JNK Signaling Cascades, T cell receptor signaling, TGFβ Smad signaling, Warburg Effect

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P01111

Product: Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only