Product Description

NRBP Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES10837-50, ES10837-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: caution:Author states that kinase activity observed in PubMed:11956649 may be due to sample contamination. This protein is predicted to be catalytically inactive.,domain:The protein kinase domain is predicted to be catalytically inactive.,function:May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subcellular location:Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia.,subunit:Homodimer. Binds to MLF1, recruiting a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 binds to YWHAZ and is retained in the cytoplasm.,tissue specificity:Ubiquitously expressed in all tissues examined with high levels in the testis.,

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from part region of human protein

Isotype: IgG

Target: NRBP

Specificity: NRBP Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Ubiquitously expressed in all tissues examined with high levels in the testis,

Observed Band (KD): 58kD

Function: Caution: Author states that kinase activity observed in PubMed: 11956649 may be due to sample contamination. This protein is predicted to be catalytically inactive
Domain: The protein kinase domain is predicted to be catalytically inactive
Function: May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication
Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family
Similarity: Contains 1 protein kinase domain
Subcellular Location: Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia
Subunit: Homodimer. Binds to MLF1, recruiting a serine kinase which phosphorylates

Subcellular Location: Cytoplasm, cell cortex Endomembrane system Cell projection, lamellipodium Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia

Storage and Stability: -20°C/1 year

Gene Name: NRBP1 BCON3 NRBP

Protein Name: Nuclear receptor-binding protein

Mouse SwissProt Number: Q99J45

Research Use Only