Product Description

Nrf3 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES2986-50, ES2986-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18. [provided by RefSeq, Mar 2009],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Alternate Names: NFE2L3, NRF3, Nuclear factor erythroid 2-related factor 3, NF-E2-related factor 3, NFE2-related factor 3, Nuclear factor, erythroid derived 2, like 3

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human NFE2L3. AA range:491-540

Isotype: IgG

Target: Nrf3

Specificity: Nrf3 Polyclonal Antibody detects endogenous levels of Nrf3 protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Highly expressed in human placenta and also in B-cell and monocyte cell lines, Low expression in heart, brain, lung, skeletal muscle, kidney and pancreas,

Observed Band (KD): 75kD

Function: Function: Activates erythroid-specific, globin gene expression
Similarity: Belongs to the bZIP family
Similarity: Belongs to the bZIP family. CNC subfamily
Similarity: Contains 1 bZIP domain
Subunit: Heterodimer with MAFG, MAFK and other small MAF proteins that binds to the MAF recognition elements (MARE)
Tissue Specificity: Highly expressed in human placenta and also in B-cell and monocyte cell lines. Low expression in heart, brain, lung, skeletal muscle, kidney and pancreas

Subcellular Location: Nucleus

Storage and Stability: -20°C/1 year

Gene Name: NFE2L3

Protein Name: Nuclear factor erythroid 2-related factor 3

Mouse SwissProt Number: Q9WTM4

Research Use Only