Product Description

NSUN5 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES10073-50, ES10073-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of an evolutionarily conserved family of proteins that may function as methyltransferases. This gene is located in a larger region of chromosome 7 that is deleted in Williams-Beuren syndrome, a multisystem developmental disorder. There are two pseudogenes for this gene located in the same region of chromosome 7. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human protein. at AA range: 320-400

Isotype: IgG

Target: NSUN5

Specificity: NSUN5 Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Ubiquitous (PubMed:11978965, PubMed:12073013), Detected in placenta, heart and skeletal muscle (PubMed:11978965, PubMed:12073013),

Observed Band (KD): 47kD

Function: Function: May have S-adenosyl-L-methionine-dependent methyl-transferase activity
PTM: Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR
Similarity: Belongs to the methyltransferase superfamily. RsmB/NOP family
Tissue Specificity: Ubiquitous. Detected in placenta, heart and skeletal muscle

Subcellular Location: Nucleus, nucleolus

Storage and Stability: -20°C/1 year

Gene Name: NSUN5 WBSCR20 WBSCR20A

Protein Name: Putative methyltransferase NSUN5 (EC 2.1.1.-) (NOL1-related protein) (NOL1R) (NOL1/NOP2/Sun domain family member 5) (Williams-Beuren syndrome chromosomal region 20A protein)

Mouse SwissProt Number: Q8K4F6

Research Use Only