NT5E Monoclonal Antibody - BT-MCA3695

NT5E Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3695-50, BT-MCA3695-100

Citations, Manuals and MSDS Available upon request.

Background: 5'-nucleotidase, ecto (NT5E), also known as CD73 (Cluster of Differentiation 73). Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase; EC 3.1.3.5) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. The enzyme consists of a dimer of 2 identical 70-kD subunits bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane. The enzyme is used as a marker of lymphocyte differentiation. Consequently, a deficiency of NT5 occurs in a variety of immunodeficiency diseases (e.g., see MIM 102700, MIM 300300). Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate.

Research Areas: Cardiovascular

Target Protein: NT5E

Applications: IHC

Reactivity: Human

Clonality: Monoclonal

Clone ID: 1D7

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: NT5E

Immunogen: Purified recombinant fragment of NT5E expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 70kDa

UniProt Accession: P21589

Synonyms: eN, NT5, CD73

GeneID: 4907

Research Use Only