Product Description

NTN Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES4375-50, ES4375-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: neurturin(NRTN) Homo sapiens This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. [provided by RefSeq, Aug 2016],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Alternate Names: NRTN, Neurturin

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human NRTN. AA range:111-160

Isotype: IgG

Target: NTN

Specificity: NTN Polyclonal Antibody detects endogenous levels of NTN protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Melanoma, Peripheral blood lymphocyte,

Observed Band (KD): 22kD

Function: Disease: Defects in NRTN are a cause of Hirschsprung disease (HSCR) [MIM: 142623]. In association with mutations of RET gene, and possibly with other loci, defects in NRTN are involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction
Function: Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells
Similarity: Belongs to the TGF-beta family. GDNF subfamily
Subunit: Homodimer, disulfide-linked

Subcellular Location: Secreted

Storage and Stability: -20°C/1 year

Gene Name: NRTN

Protein Name: Neurturin

Mouse Gene ID: 18188

Mouse SwissProt Number: P97463

Research Use Only