Product Description

Nuclear Receptor NR4A1 (Phospho-Ser351) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES14439-50, ES14439-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: Nuclear receptor subfamily 4 group A member 1 (Early response protein NAK1, Nuclear hormone receptor NUR/77, Nur77, Orphan nuclear receptor HMR, Orphan nuclear receptor TR3, ST-59, Testicular receptor 3)

Clonality: Polyclonal

Immunogen: Synthesized pospho peptide derived from human Nuclear Receptor NR4A1 (Phospho-Ser351)

Isotype: IgG

Target: Nur77

Specificity: This antibody detects endogenous pospho levels of human Nuclear Receptor NR4A1 (Phospho-Ser351)

Dilution: WB 1:500-2000, ELISA(peptide)1:5000-20000

Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Fetal muscle and adult liver, brain and thyroid,

Observed Band (KD): 77kD

Fields: MAPK signaling pathway, PI3K-Akt signaling pathway, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Cushing syndrome

Function: Function: Orphan nuclear receptor
Induction: By growth-stimulating agents
Similarity: Belongs to the nuclear hormone receptor family
Similarity: Belongs to the nuclear hormone receptor family. NR4 subfamily
Similarity: Contains 1 nuclear receptor DNA-binding domain
Subunit: Interacts with GADD45GIP1
Tissue Specificity: Fetal muscle and adult liver, brain and thyroid

Subcellular Location: Nucleus Cytoplasm Mitochondrion Nuclear export to the cytoplasm is XPO1-mediated and positively regulated by IFI27 (PubMed:22427340) Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (PubMed:17761950)

Storage and Stability: -20°C/1 year

Gene Name: NR4A1 GFRP1 HMR NAK1

Protein Name: Nuclear Receptor NR4A1 (Phospho-Ser351)

Research Use Only