Product Description

NUMB Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES4050-50, ES4050-100

Lead times: approximately 7-10 business days, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IF, ELISA

Alternate Names: NUMB; Protein numb homolog; h-Numb; Protein S171

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from the Internal region of human NUMB.

Isotype: IgG

Target: NUMB,

Specificity: NUMB Polyclonal Antibody detects endogenous levels of NUMB protein.

Dilution: WB 1:500-2000; IF/ICC 1:100-500;ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: B cells, Blood, Brain, Cervix carcinoma, Epithelium, Fetal brain, HeLa cells, Live

Observed Band (KD): 70kD

Fields: Notch signaling pathway

Function: Implicated in the control of cell fate decisions during development. PTM: Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity). Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation. sequence Caution: Intron retention. Similarity: Contains 1 PID domain. Subunit: Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis.

Subcellular Location: Cell membrane, Peripheral membrane protein, Cytoplasmic side Endosome membrane, Peripheral membrane protein, Cytoplasmic side Localizes to perinuclear endosomes in an AAK1-dependent manner.

Storage and Stability: -20°C/1 year

Gene Name: NUMB

Protein Name: Protein numb homolog

Human Gene ID: 8650

Human SwissProt Number: P49757

Mouse Gene ID: 18222

Mouse SwissProt Number: Q9QZS3

Rat SwissProt Number: Q2LC84

Research Use Only