Nup98 Monoclonal Antibody - BT-MCA0951

Nup98 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA0951-50, BT-MCA0951-100

Citations, Manuals and MSDS Available upon request.

Background: Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of

Research Areas: Epigenetics and nuclear signaling; Signal transduction

Target Protein: NUP98

Applications: WB

Reactivity: Human,Mouse,Dog

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Nuclear pore complex protein Nup98-Nup96

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P52948

Synonyms: NUP98; ADAR2; Nuclear pore complex protein Nup98-Nup96

GeneID: Human: 4928

Research Use Only