NUP98 Monoclonal Antibody - BT-MCA4369

NUP98 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4369-50, BT-MCA4369-100

Citations, Manuals and MSDS Available upon request.

Background: Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin.

Research Areas: Epigenetics and nuclear signaling, Signal transduction

Target Protein: NUP98

Applications: WB, ICC, FCM

Clonality: Monoclonal

Clone ID: 3G8C7

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: NUP98

Immunogen: Purified recombinant fragment of human NUP98 (AA: 1-218) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 197.5kDa

UniProt Accession: P52948

Synonyms: ADIR2, NUP96, NUP196, Nup98-96

GeneID: 4928

Research Use Only